We’ve brought together three leading specialists to share clear, practical insights into mastocytosis, idiopathic mast cell activation syndrome (MCAS) and symptomatic hereditary alpha tryptasemia (HaT).
These interviews are designed to support understanding, improve awareness and help patients, families and communities navigate complex and often misunderstood conditions.
Video captions are available in nine languages: English, Dutch, French, German, Italian, Polish, Portuguese, Romanian and Spanish. Caption language should automatically adjust based on your device settings.
Mastocytosis
With more than 16 years of experience, Dr Deepti Radia, Consultant Haematologist at Guy’s and St Thomas’ Hospital, London, reflects on how understanding of mastocytosis has evolved.
In this interview, she explains why getting the diagnosis right matters and how accurate classification can influence care and quality of life.
Idiopathic Mast Cell Activation Syndrome (MCAS)
Idiopathic MCAS occurs when mast cells release too many mediators, causing symptoms, but no underlying cause can be identified.
In an insightful interview, Dr Mariana Castells (Brigham and Women’s Hospital, Boston) offers insight into care for people living with idiopathic MCAS.
Hereditary Alpha Tryptasemia (HaT)
Hereditary alpha tryptasemia (HaT) is a genetic trait linked to extra copies of the tryptase gene. For many people it causes no symptoms, but for others it can contribute to a wide range of issues, such as rashes, itching and flushing; food or chemical sensitivities; gastrointestinal symptoms; musculoskeletal and joint pain; and, in some cases, an increased risk of anaphylaxis.
Dr Sarah Glover (Tulane University School of Medicine) explains what symptomatic HaT is, how it can show up and why it can feel like a long road – “a marathon, not a sprint”.
Thank you
We hope these insights help raise awareness and encourage greater understanding of the challenges faced by those living with mast cell diseases around the world.
We would like to extend our thanks to our Platinum Sponsor, Blueprint Medicines, and Gold Sponsor, Cogent Biosciences, for sponsoring this global health initiative to help inform and connect the mast cell diseases community.
We also thank our content partner, RARE Revolution Magazine, for their support and creativity in amplifying awareness through informative content and patient perspectives.
Disclaimer
The information shared in these interviews is intended for general education and awareness only. It should not be used as a substitute for professional medical advice. Viewers are encouraged to seek guidance from their own healthcare provider regarding individual health concerns.